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Carcinogenic N-nitroso compounds and their environmental significance

โœ Scribed by R. Preussmann

Publisher
Springer
Year
1984
Tongue
English
Weight
527 KB
Volume
71
Category
Article
ISSN
0028-1042

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โœฆ Synopsis

A short review is given on the potent and organ-specific carcinogenic effects of N-nitroso compounds. Like many other chemical carcinogens, nitrosamino compounds require activation in vivo via enzymatic alpha-hydroxylation to form alkylating agents as ultimate carcinogens. Since no epidemiological data in man are available, extrapolation of animal data to man are important as well as dose-response studies in risk evaluations. Important aspects of these problems are presented. Finally the environmental impact of N-nitroso compounds is summarized.

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## Abstract Four known carcinogenic compounds, all of which contain the nitroso group, have been found to be effective in producing cell killing, chromatid breaks, mutagenesis and chromatid rearrangements in Chinese hamster ovary cells. Single cell survival curves revealed these agents to exhibit a