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Carcinogenic evaluation of 2,3-dimethyl-2,3-dinitrobutane via the mouse skin bioassay

✍ Scribed by Tirumuru V. Reddy; F. Bernard Daniel; Merrel Robinson; Greg R. Olson

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
149 KB
Volume
14
Category
Article
ISSN
0260-437X

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✦ Synopsis

Female SENCAR mice initiated with 2,3-dimethyl-2,3-dinitrobutane (DMDNB) and promoted with 12-0tetradecanoylphorol-13-acetate (TPA) via the SENCAR mouse skin bioassay did not exhibit a significant increase in skin tumors. The mice received 20 mg kg-' DMDNB divided into six intragastric doses over 2 weeks and were promoted three times per week for 20 weeks.

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