Carcinogenic Effect of a Dimethyl Sulphoxide Extract of Betel Nut on the Mucosa of the Hamster Buccal Pouch
β Scribed by SURI, KAILASH; GOLDMAN, HENRY M.; WELLS, HERBERT
- Book ID
- 109677455
- Publisher
- Nature Publishing Group
- Year
- 1971
- Tongue
- English
- Weight
- 466 KB
- Volume
- 230
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/230383a0
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## Abstract The present study evaluates the incidence of tumors in hamster buccal pouches following shortβterm (10 days) and longβterm (6 months) topical exposures to graded doses of benzo(a)pyrene, B(a)P (25 ΞΌg, 50 ΞΌg and 100 ΞΌg per pouch either daily for 10 days or thrice weekly for 6 months) alo
The frequency of exfoliated cells with micronuclei in buccal swabs was used to estimate the protective effect of vitamin A, beta-carotene and canthaxanthin (4,4'-diketo-beta-carotene) on the buccal mucosa of betel (areca) nut/tobacco chewers. Micronuclei were scored on exfoliated cells taken by swab