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Carcinogenic and possible mutagenic effects of stilboestrol in offspring exposed in utero

✍ Scribed by Dr. N. P. Bishun; N. S. Smith; D. C. Williams; R. W. Raven

Publisher: John Wiley and Sons
Year: 1977
Tongue: English
Weight: 558 KB
Volume: 9
Category: Article
ISSN: 0022-4790
DOI: 10.1002/jso.2930090312

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The relevant literature has been reviewed and it appears that there is no doubt that in utero exposure to stilboestrol is related to the eventual development of vaginal adenocarcinoma in young females. Although cancers of other types are also prevalent, the incidence is not great and may be related to other types of drugs taken during pregnancy. The review attempts to correlate the genetic effects with the abnormal development, but on account of the scarcity of data such correlation is not possible. Further work on the genetic effects and the development of the lower genital tract in the female needs to be carried out.

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