## Abstract Nonmelanoma skin cancer (NMSC) is the most frequently diagnosed cancer in the United States. Deregulation of bclβ2 and ras family members is commonly observed in NMSC. It has been previously demonstrated that simultaneous bclβ2 and Haβras gene expression in keratinocytes results in diso
Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis
β Scribed by Quintanilla, Miguel; Brown, Ken; Ramsden, Martin; Balmain, Allan
- Book ID
- 109744178
- Publisher
- Nature Publishing Group
- Year
- 1986
- Tongue
- English
- Weight
- 403 KB
- Volume
- 322
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/322078a0
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## Abstract Tumor angiogenesis is governed by a complex balance of positive and negative angiogenic factors. Development of chemicallyβinduced mouse skin tumors appears to be highly dependent on an early burst of neovascularization. We have previously shown that Haβ__ras__βdriven vascular endotheli