Carcinogen exposure, p53 alteration, and K-ras mutation in synchronous multiple primary lung carcinoma
✍ Scribed by Xi Wang; David C. Christiani; Eugene J. Mark; Heather Nelson; John K. Wiencke; Laura Gunn; John C. Wain; Karl T. Kelsey
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 73 KB
- Volume
- 85
- Category
- Article
- ISSN
- 0008-543X
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✦ Synopsis
BACKGROUND. Synchronous multiple primary lung tumors (SMPLT) have been estimated to occur in 1% of lung carcinoma patients. Criteria for SMPLT diagnosis include different cancer histologies, location in different lobes of the lung, or genetic discordance. Patients with SMPLT have a poor clinical prognosis with decreased 5-year disease survival, despite diagnosis at an early stage. Field cancerization (the induction of somatic mutation in large clones of epithelial cells after carcinogen exposure) has been proposed to be an integral process involved in the development of SMPLT. Host factors also may contribute to the development of SMPLT.
METHODS.
The authors investigated the occurrence of p53 and K-ras alterations in tumors from SMPLT patients and also studied the association between carcinogen exposure and polymorphic metabolic traits in SMPLT patients, comparing these patients with individuals with one primarily lung tumor.