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Carcinogen dose-dependent variation in the transgene mutation spectrum in urethane-induced lung tumors in transgenic mice carrying the human prototype c-Ha-ras gene

โœ Scribed by Ikuo Mori; Kazuo Yasuhara; Shim-mo Hayashi; Takashi Nonoyama; Tatsuji Nomura; Kunitoshi Mitsumori


Book ID
117466477
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
876 KB
Volume
153
Category
Article
ISSN
0304-3835

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To determine if hemizygous transgenic mice carrying the human c-Ha-ras gene (CB6F1-Tg Hras2 mice (Hras2 mice)) are susceptible to the carcinogenic potential of known murine carcinogens, male and female Hras2 mice and their non-transgenic CB6F1 littermates (non-Tg mice) were each given a single intra