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Carcinogen activation by human liver enzymes in the ames mutagenicity test

✍ Scribed by Terry Tang; Marvin A. Friedman


Book ID
113248918
Publisher
Elsevier Science
Year
1977
Tongue
English
Weight
490 KB
Volume
46
Category
Article
ISSN
0165-1161

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The mutagenicity of tetrachloroethene (tetra) and its S conjugate, S-(1,2,2-trichlorovinyl)glutathione (TCVG) was investigated using a modified Ames preincubation assay. TCVG was a potent mutagen in presence of rat kidney particulate fractions containing high concentrations of y-glutamyl transpeptid