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Carcinoembryonic antigen in carcinoma of the uterine cervix: Antigen distribution in primary and metastatic tumors

✍ Scribed by J. R. Van Nagell Jr; S. Hudson; E. C. Gay; E. S. Donaldson; M. Hanson; D. F. Powell; D. M. Goldenberg

Publisher
John Wiley and Sons
Year
1982
Tongue
English
Weight
636 KB
Volume
49
Category
Article
ISSN
0008-543X

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✦ Synopsis

Immunohistochemical staining for carcinoembryonic antigen (CEA) was performed on primary tumors and regional lymph nodes from 100 patients undergoing radical hysterectomies and pelvic lymphadenectomies for invasive carcinoma of the uterine cervix. Antigen staining was present in 82% of keratinizing squamous carcinomas as compared with 50% in nonkeratinizing tumors. Seventeen patients with CEA-producing cervical cancer had regional lymph nodes metastases, all of which stained positively for CEA. Conversely, antigen could not be detected in lymph nodal metastases from primary tumors devoid of CEA. The pattern and intensity of CEA staining in primary tumors and their metastases were similar in all cases. Antigen was present in highest concentrations in the cytoplasm and tumor cell membrane of all tissues examined and isolated nuclear staining was absent. The clinical implications of these findings are discussed.

Cancer 49:379-383, 1982.

INCE ITS INITIAL description in patients with ade-

S nocarcinoma of the ~010n,~3~ carcinoembryonic antigen (CEA) has been demonstrated in the plasma and tumors of patients with a variety of neoplasms. In gynecologic cancer, CEA has been isolated in highest concentrations in mucinous cystadenocarcinomas of the ovary and in both adenocarcinomas and squamous cell carcinomas of the c e r v i ~. ' , ' ~-' ~ To date, the major clinical usefulness of CEA has been as a biologic marker for predicting occult recurrences in patients whose tumors contain high antigen levels. Immunohistochemical staining as a means of identifying antigenic markers in tumor tissue was first suggested by Nakane and Peroxidase-labeled antibodies were prepared and the site of immunologic reactivity was identified by a histochemical reaction. The successful tissue localization of CEA, using a refined immunoperoxidase From the

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Immunoperoxidase staining for carcinoembryonic antigen (CEA) was performed on the tumors of 241 patients with invasive carcinoma of the cervix. Positive tissue staining indicative of a CEA concentration of at least 3 pg/gm was present in 154 tumors (63%) as opposed to 0 of 30 specimens of normal cer

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The skillful help of Mrs. M. C. de Boer-Bisschops, Mrs. C. Kosterman-Claassen, Mr. R. Lodewijks, and Mrs. U. M. R. Vrij in performing the CEA assay, and of Mrs. A. Graafmans and Mrs. A. J. M. Pieterson-Scholts in collecting and handling the bloodsamples, is gratefully acknowledged.