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Carboxyl Methylation of Protein Phosphatase 2A from Xenopus Eggs Is Stimulated by cAMP and Inhibited by Okadaic Acid

✍ Scribed by M. Floer; J. Stock


Book ID
115574087
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
358 KB
Volume
198
Category
Article
ISSN
0006-291X

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The involvement of serine/threonine protein phosphatases in signaling pathways that control the expression of the cyclooxygenase-2 (COX-2) gene in human chondrocytes was examined. Okadaic acid (OKA), an inhibitor of protein phosphatases 1 (PP-1) and 2A (PP-2A), induced a delayed, time-dependent incr