Carboxybetaine Polymer-Protected Gold Nanoparticles: High Dispersion Stability and Resistance against Non-Specific Adsorption of Proteins
✍ Scribed by Kazuhiro Matsuura; Kohji Ohno; Shigehiro Kagaya; Hiromi Kitano
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 353 KB
- Volume
- 208
- Category
- Article
- ISSN
- 1022-1352
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✦ Synopsis
Abstract
1‐Carboxy‐N,N‐dimethyl‐N‐(2′‐methacryloyloxyethyl)methanaminium inner salt (CMB) was polymerized by ATRP initiated with a disulfide difunctionalized by 2‐bromoisobutyryl groups. The disulfide‐carrying carboxybetaine polymer (DT‐PCMB) was used for the preparation of PCMB‐protected gold nanoparticles (PCMB‐AuNPs) obtained by the reduction of hydrogen tetrachloroaurate (HAuCl~4~) in the presence of the DT‐PCMB of different molecular weights at different molar ratios of DT‐PCMB and HAuCl~4~. The sizes of gold cores in the PCMB‐AuNPs tended to increase upon decreasing concentration and molecular weight of the DT‐PCMB. The PCMB‐AuNPs possessed a high dispersion stability, and showed a resistance against non‐specific adsorption of proteins (bovine serum albumin, human serum albumin, lysozyme, and cytochrome c). Therefore, DT‐PCMB is a quite suitable stabilizing ligand to prepare inert AuNPs and the PCMB‐AuNPs will be useful in biomedical applications.
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