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Carboplatin-induced alteration of the thiol homeostasis in the isolated perfused rat kidney

✍ Scribed by Daniela Giustarini; Isabella Dalle-Donne; Eugenio Paccagnini; Aldo Milzani; Ranieri Rossi

Book ID
116178453
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
298 KB
Volume
488
Category
Article
ISSN
0003-9861

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Alterations in intracellular thiol homeo
Alterations in intracellular thiol homeostasis during the metabolism of menadione by isolated rat hepatocytes
✍ Donato Di Monte; David Ross; Giorgio Bellomo; Lena EklΓΆw; Sten Orrenius πŸ“‚ Article πŸ“… 1984 πŸ› Elsevier Science 🌐 English βš– 822 KB

The effects of menadione (2-methyl-1,4-naphthoquinone) metabolism on intracellular soluble and protein-bound thiols were investigated in freshly isolated rat hepatocytes. Menadione was found to cause a dose-dependent decrease in intracellular glutathione (GSH) level by three different mechanisms: (a