A trend toward the use of prolonged postoperative chemotherapy, with radiotherapy deferred until relapse, has emerged for very young children with malignant brain tumors. This study was undertaken to determine the failure patterns among infants who receive such treatment and to evaluate their respon
Carboplatin-based primary chemotherapy for infants and young children with CNS tumors
โ Scribed by Maryam Fouladi; Sri Gururangan; Albert Moghrabi; Peter Phillips; Lindsey Gronewold; Dana Wallace; Robert A. Sanford; Amar Gajjar; Larry E. Kun; Richard Heideman
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 215 KB
- Volume
- 115
- Category
- Article
- ISSN
- 0008-543X
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Carboplatin is less ototoxic than cisplatin, but ototoxicity may occur with carboplatin at higher doses. We evaluated hearing in children with brain tumors treated with conventional dose cisplatin followed by highdose carboplatin. Children under 6 years of age, newly diagnosed with brain tumors, wer
## Background: Chemotherapy may be used to delay the need for cranial irradiation in infants and young children with malignant central nervous system (cns) tumors. the polyfunctional alkylator thiotepa (tt) possesses significant in vitro and in vivo activity in many central nervous system tumors. b