Carbonylation of alkynols catalyzed by Pd(II)/2-PyPPh2 dissolved in organic solvents and in ionic liquids: a facile entry to α-methylene γ- and δ-lactones

✍ Scribed by Crestina S Consorti; Gunter Ebeling; Jaı̈rton Dupont

• Publisher: Elsevier Science
• Year: 2002
• Tongue: French
• Weight: 94 KB
• Volume: 43
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)02309-7

✦ Synopsis

The carbonylation of terminal 3-alkyn-1-ols and 1-alkyn-4-ols by Pd(OAc) 2 associated with 2-(diphenylphosphino)pyridine (2-PyPPh 2 ) dissolved in organic solvents or in 1-n-butyl-3-methyl imidazolium ionic liquids affords quantitatively and selectively exo-a-methylene gand d-lactones, respectively. In the case of the reactions performed in ionic liquids (biphasic conditions), the lactones were isolated by simple distillation and the ionic catalyst solution can be reused.