Carbonic anhydrase II is induced in HL-60 cells by 1,25-dihydroxyvitamin D3: A model for osteoclast gene regulation
β Scribed by Linda Hillstrom Shapiro; Patrick J. Venta; Ya-Shiou L. Yu; Richard E. Tashian
- Book ID
- 115921868
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 476 KB
- Volume
- 249
- Category
- Article
- ISSN
- 0014-5793
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The physiologically active form of vitamin D, 1a,25-dihydroxyvitamin D 3 (1,25D 3 ), induces promyelocytic HL60 cells to differentiate towards monocytelike cells. During this differentiation increased cytosolic calcium (Ca 2/ i ) and expression of surface receptors for chemotactic factors ''prime''
## Abstract We are interested in determining the signaling pathways for 1,25βdihydroxyvitamin D~3~ (1,25D)βinduced differentiation of HL60 leukemic cells. One possible candidate is Rafβ1, which is known to signal cell proliferation and neoplastic transformation through MEK, ERK, and downstream targ