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Carbon tetrachloride-induced inhibition of protein kinase C in isolated rat hepatocytes

✍ Scribed by Giuseppe Poli; Emanuele Albano; Mario U. Dianzani; Edon Melloni; Sandro Pontremoli; Umberto M. Marinari; Maria Adelaide Pronzato; Damiano Cottalasso

Book ID
117058568
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
364 KB
Volume
153
Category
Article
ISSN
0006-291X

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The protein kinase C (PKC) family of isoenzymes plays a key role in the regulation of hepatocellular secretion. The hydrophobic and cholestatic bile acid, taurolithocholic acid (TLCA), acts as a potent Ca++ agonist in isolated hepatocytes. However, its effect on PKC isoforms has not been elucidated.