Carbon dioxide gas as a perfusion medium for the sapphire probe in laser ablation of human atheromatous plaques: Comparison study with saline
✍ Scribed by Xiaoming Yang; Hannu Manninen; Jussi P. Kankkunen; Hongxiu Ji; Anita Naukkarinen; Matti Suhonen; Seppo Soimakallio
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 569 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0196-8092
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✦ Synopsis
The effectiveness of CO, gas as a perfusion medium was compared to that of saline in laser ablation of human atheromatous plaque. In an experimental circulation-occlusion model using flowing whole blood, human cadaveric arterial samples were ir- radiated by a sapphire probe with the Nd-YAG laser. The following experiments were performed: 1) lasing without perfusion, 2) lasing with saline perfusion of the probe, and 3) lasing with CO, perfusion. Different perfusion flow rates of saline and CO, were used. Results showed that the mean ablation area was 1.6-fold larger with CO, than with saline perfusion (P < 0.05, Student's t test). The mean lateral injury at the site adjacent to the ablation crater and at the area directly facing the probe was not significantly different with either perfusion medium. The larger ablation area with CO, was probably due to the fact that CO, is a good insulator for maintaining a higher probe temperature and keeps the probe free of blood debris. In conclusion, our results show that CO, perfusion facilitates more effective laser ablation of atheromatous plaque than saline perfusion by the sapphire probe with the continuous wave Nd-YAG laser.