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Carbon-14 labelled nitrogen heterocycles; the syntheses of three phosphodiesterase inhibitors

✍ Scribed by Kenneth W M Lawrie; Christine E A Novelli; David Saunders; William J Coates

Publisher
John Wiley and Sons
Year
1995
Tongue
French
Weight
362 KB
Volume
36
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The syntheses of three heterocyclic phosphodiesterase inhibitors are described from a common radiolabelled precursor, namely 2‐propoxybenzo[cyano‐^14^C]nitrile. Conversion of the nitrile to the corresponding methyl ketone or amidine allows elaboration of the heterocycles radiolabelled within the ring systems.

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