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Carbon-13 and proton NMR studies of the interaction of tricyclic antidepressant drugs with micellar aggregates

โœ Scribed by Casarotto, Marco G.; Craik, David J.

Book ID
121340364
Publisher
American Chemical Society
Year
1991
Tongue
English
Weight
839 KB
Volume
95
Category
Article
ISSN
0022-3654

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โœ Jennifer C. Wilson; Sharon L. A. Munro; David J. Craik ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 710 KB

The solution conformations and dynamics of the antidepressant drug trimipramine maleate were investigated by 'H and I3C NMR spectroscopy. Of particular interest was an observed non-equivalence of the N-methyl groups in the aliphatic sidechain of the drug, which is present in both 'H and I3C spectra