## Abstract A convenient synthesis of [N‐methyl‐^11^C]‐3‐[(6‐dimethylamino)pyridin‐3‐yl]‐2,5‐dimethyl‐__N__,__N__‐dipropylpyrazolo[1,5‐a]pyrimidine‐7‐amine (R121920), a highly selective CRF~1~ antagonist has been developed as a potential PET ligand. 3 ‐ [(6 ‐ methylamino)pyridin ‐ 3 ‐ yl]‐2,5‐dimet
✦ LIBER ✦
Carbon-11 N-methyl alkylation of L-368,899 and in vivo PET imaging investigations for neural oxytocin receptors
✍ Scribed by Smith, Aaron L.; Freeman, Sara M.; Voll, Ronald J.; Young, Larry J.; Goodman, Mark M.
- Book ID
- 120488281
- Publisher
- Elsevier Science
- Year
- 2013
- Tongue
- English
- Weight
- 962 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0960-894X
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## Abstract 2‐(4‐Methoxyphenyl)‐__N__‐(4‐methylbenzyl)‐__N__‐(1‐methylpiperidin‐4‐yl)acetamide (AC90179, **4**), a highly potent and selective competitive 5‐HT~2A~ antagonist, was labeled by [^11^C]‐methylation of the corresponding desmethyl analogue **5** with [^11^C]methyl triflate. The precursor