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Carbohydrates in Chemistry and Biology || Developmental and Aging Changes of Chondroitin/Dermatan Sulfate Proteoglycans

โœ Scribed by Ernst, Beat; Hart, Gerald W.; Sina, Pierre


Publisher
Wiley-VCH Verlag GmbH
Year
2000
Tongue
German
Weight
916 KB
Edition
1
Category
Article
ISBN
3527295119

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โœฆ Synopsis


Carbohydrate Chemistry and Glycobiology have witnessed a rapid expansion during the last few years with the development of numerous new, imaginative and efficient syntheses which provide further insight into structures and biological interactions of glycoconjugates. Glycosylation reactions are widely used in the synthesis of pharmaceuticals and bio-active compounds. In biology and medicine oligosaccharides play a central role in immuno-stimulation, cancer or allergic responses. Glycoscience is a very instructive example of how one common topic of interest stimulates both chemistry and biology to collectively open scientific frontiers.
This synergy is made visible in this work. Three leading experts in the fields of Glycochemistry and Glycobiology have invited numerous renowned authors to provide a comprehensive overview of the recent advances and findings in Glycoscience. This four-volume handbook presents an integrated and cutting-edge view, and covers all chemical aspects, such as syntheses and analysis of carbohydrates and oligosaccharides, as well as the biological role and activity of oligosaccharides and carbohydrate/protein interactions.


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Changes in the amounts of chondroitin su
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## Abstract Chondroitin sulfate proteoglycans have been shown to participate in the pathogenesis of neuronal damages in the injured adult central nervous system (CNS). Upregulated expression of chondroitin sulfate proteoglycans has been reported around the injured sites and depletion of these chond