Carbohydrates as Multifunctional Chiral Scaffolds in Combinatorial Synthesis

✍ Scribed by Tobias Wunberg; Christopher Kallus; Till Opatz; Stefan Henke; Wolfgang Schmidt; Horst Kunz

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 92 KB
• Volume: 37
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/(sici)1521-3773(19981002)37:18<2503::aid-anie2503>3.0.co;2-r

✦ Synopsis

Four orthogonally stable protecting groups and a selectively cleavable anchor that are stable under basic conditions are required in order that carbohydrates can be employed as chiral polyfunctional scaffolds in combinatorial solid-phase syntheses of high diversity. The schematic representation shows the combinatorial synthesis with a carbohydrate scaffold (SG=protecting group, A=anchor, P=polymer carrier), which proceeds by sequential selective deprotection, functionalization, washing of the solid phase, and cleavage of the anchor.