Carbohydrate biomarker recognition using synthetic lectin mimics

✍ Scribed by Dai, Chaofeng (author);Sagwal, Arpana (author);Cheng, Yunfeng (author);Peng, Hanjing (author);Chen, Weixuan (author);Wang, Binghe (author)

• Book ID: 120498781
• Publisher: International Union of Pure and Applied Chemistry
• Year: 2012
• Tongue: English
• Weight: 1018 KB
• Volume: 84
• Category: Article
• ISSN: 0033-4545
• DOI: 10.1351/PAC-CON-12-04-17

✦ Synopsis

Carbohydrate biomarkers play very important roles in a wide range of biological and pathological processes. Compounds that can specifically recognize a carbohydrate biomarker are useful for targeted delivery of imaging agents and for development of new diagnostics. Furthermore, such compounds could also be candidates for the development of therapeutic agents. A tremendous amount of active work on synthetic lectin mimics has been reported in recent years. Amongst all the synthetic lectins, boronic-acid-based lectins (boronolectins) have shown great promise. Along this line, four classes of boronolectins including peptide-, nucleic-acid-, polymer-, and small-molecule-based ones are discussed with a focus on the design principles and recent advances. We hope that by presenting the potentials of this field, this review will stimulate more research in this area.