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Carbohydrate-based routes to salicylate natural products: formal total synthesis of (+)-apicularen A from d-glucal

✍ Scribed by Arwel Lewis; Ian Stefanuti; Simon A Swain; Stephen A Smith; Richard J.K Taylor

Book ID: 104231099
Publisher: Elsevier Science
Year: 2001
Tongue: French
Weight: 116 KB
Volume: 42
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)01038-3

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✦ Synopsis

A synthesis of apicularen analogue (-)-4 in 18 steps from D-glucal is reported. As (+)-4 has been converted into apicularen A in 8 steps, this constitutes a formal total synthesis of this potent naturally occurring anti-cancer agent.

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