Carbamazepine-induced thrombocytopenia defined by a challenge test

✍ Scribed by Ishikita, Takashi; Ishiguro, Akira; Fujisawa, Kohji; Tsukimoto, Ichiro; Shimbo, Toshikazu

• Book ID: 101215838
• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 23 KB
• Volume: 62
• Category: Article
• ISSN: 0361-8609
• DOI: 10.1002/(sici)1096-8652(199909)62:1<52::aid-ajh9>3.0.co;2-e

✦ Synopsis

Carbamazepine (CBZ), a widely used anticonvulsant, occasionally causes serious hematologic disorders. A 12-year-old boy was admitted because of a diffuse petechial rash and profound thrombocytopenia (10 × 10 9 platelets/l), after having been treated for epilepsy with CBZ for 12 days. Seven days following withdrawal of CBZ and initiation of prednisolone therapy, the platelet count recovered. In a subsequent challenge test with CBZ, platelet counts again decreased, and the levels of platelet-associated IgG and serum interleukin-6 increased. No antibodies against platelet glycoprotein IIb/IIIa or Ib were detected in plasma. We believe that this is the first reported occasion when CBZ-induced thrombocytopenia has been defined by a rechallenge test. Am.