✦ LIBER ✦

Carbamate linkers as latent N-methylamines in solid phase synthesis

✍ Scribed by Chih Y. Ho; Michael J. Kukla

Publisher: Elsevier Science
Year: 1997
Tongue: French
Weight: 173 KB
Volume: 38
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(97)00510-8

No coin nor oath required. For personal study only.

✦ Synopsis

A new linker strategy for solid phase synthesis has been developed. It utilizes LAH reduction of a carbamate connection to Wang resin which results in N-methylamines, a useful functionality in medicinal chemistry.

📜 SIMILAR VOLUMES

Triazenes as robust and simple linkers f

Triazenes as robust and simple linkers for amines in solid-phase organic synthesis

✍ Stefan Bräse; Johannes Köbberling; Dieter Enders; Ryszard Lazny; Mingfei Wang; S 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 197 KB

A new linker strategy for the attachment of aliphatic amines has been developed. Starting from Merrifield resin, an immobilized diazonium salt was prepared in two steps. Reaction of various amines gave rise to triazenes, which in turn were cleaved off upon treatment with mild acids. The triazenes ha

Carbamate Linker Strategy in Solid-Phase

Carbamate Linker Strategy in Solid-Phase Synthesis of Amino-Functionalized Glycoconjugates for Attachment to Solid Surfaces and Investigation of Protein-Carbohydrate Interactions

✍ Sara Spjut; Maciej Pudelko; Mirja Hartmann; Mikael Elofsson 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 574 KB

Hydroquinone-O,O′-diacetic acid as a mor

Hydroquinone-O,O′-diacetic acid as a more labile replacement for succinic acid linkers in solid-phase oligonucleotide synthesis

✍ Richard T. Pon; Shuyuan Yu 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 238 KB

The First Stable Diazonium Ion on Solid

The First Stable Diazonium Ion on Solid Support—Investigations on Stability and Usage as Linker and Scavenger in Solid-Phase Organic Synthesis

✍ Stefan Dahmen; Stefan Bräse 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 168 KB 👁 2 views

Gel phase 13C n.m.r. spectroscopy as an

Gel phase 13C n.m.r. spectroscopy as an analytical method in solid (gel) phase peptide synthesis

✍ R. Epton; P. Goddard; K.J. Ivin 📂 Article 📅 1980 🏛 Elsevier Science 🌐 English ⚖ 380 KB

Fmoc-protected, glycosylated asparagines

Fmoc-protected, glycosylated asparagines potentially useful as reagents in the solid-phase synthesis of N-glycopeptides

✍ Laszlo Urge; Laszlo Otvos Jr.; Emma Lang; Krzysztof Wroblewski; Ilona Laczko; Mi 📂 Article 📅 1992 🏛 Elsevier Science 🌐 English ⚖ 768 KB

1-Amino 1-deoxy derivatives of unprotected O-beta-D-galactopyranosyl-(1-->3)-2-acetamido-2-deoxy-beta-D-glucopyrano se, 2-acetamido-2-deoxy-D-galactose, D-galactose, lactose, D-fucose, D-mannose, and 2-deoxy-D-arabino-hexose were prepared and acylated with N-fluorenylmethoxycarbonylaspartic acid alp