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Captopril reduces collagen and mast cell and eosinophil accumulation in pig serum-induced rat liver fibrosis

✍ Scribed by Simone G. Ramos; André P. Montenegro; Gilberto Goissis; Marcos A. Rossi


Book ID
115175127
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
843 KB
Volume
44
Category
Article
ISSN
1320-5463

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Hepatic fibrosis was induced in rats by repeated i.p. injections of pig serum. The hepatic hydroxyproline content increased to 2.1 times the normal control level at 6 weeks and to 3.2 times at 10 weeks. When P-l894B, an inhibitor of prolyl hydroxylase, was administered, there was a dose-dependent in