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Capsaicin reduces the zosteriform spread of genital herpes simplex virus infection in guinea pigs

✍ Scribed by L.R. Stanberry; N. Bourne; F.J. Bravo; D.I. Bernstein


Book ID
118392649
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
71 KB
Volume
15
Category
Article
ISSN
0166-3542

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Capsaicin-sensitive peptidergic neurons
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## Abstract The intraneuronal transport of herpes simplex virus (HSV) is an essential component in disease pathogenesis. Capsaicin, a neuropharmacologic agent lacking direct antiviral activity, has been shown to protect animals against HSV‐induced disease. It has been hypothesized that capsaicin ac

Outcome of herpes simplex virus type 2 i
✍ Sandra L. Fowler; Christopher J. Harrison; Martin G. Myers; Lawrence R. Stanberr πŸ“‚ Article πŸ“… 1992 πŸ› John Wiley and Sons 🌐 English βš– 574 KB

## Abstract Factors that influence the outcome of genital herpes simplex virus (HSV) infection were explored in a guinea pig model. The viral inoculum required to establish infection in 50% of animals (ID~50~) was similar for inbred (strain 2) and out‐bred (Hartley) guinea pigs. However, the viral