Capnellenes from the Soft Coral Dendronephthya rubeola

✍ Scribed by Daniela Grote; Frank Hänel; Hans-Martin Dahse; Karlheinz Seifert

• Book ID: 101776184
• Publisher: John Wiley and Sons
• Year: 2008
• Tongue: English
• Weight: 197 KB
• Volume: 5
• Category: Article
• ISSN: 1612-1872
• DOI: 10.1002/cbdv.200890157

✦ Synopsis

Abstract

Four new acetoxycapnellenes 1–4, the first epoxyprecapnellene 5, along with the known dihydroxycapnellene 6 and monoacetoxycapnellene 7, have been isolated from the soft coral Dendronephthya rubeola. The structures were determined primarily by NMR spectroscopy. The compounds 6 and 7 showed a good antiproliferative activity against the cell line L‐929 (murine fibroblasts) and a good cytotoxic activity against the HeLa (human cervix carcinoma) cell line. Compound 6 strongly inhibits the interaction of the oncogenic transcription factor Myc with its partner protein Max. Myc/Max‐Interaction inhibitors are therapeutically interesting compounds in oncology.