✦ LIBER ✦

Capillary physiology and drug delivery in central nervous system lymphomas

✍ Scribed by Peter C. Warnke; Jens Timmer; Christoph B. Ostertag; Klaus Kopitzki

Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 236 KB
Volume: 57
Category: Article
ISSN: 0364-5134
DOI: 10.1002/ana.20335

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

To evaluate whether the chemosensitivity of primary central nervous system lymphomas to water‐soluble drugs could result from improved drug delivery, we quantitatively assessed pharmacokinetic factors in seven patients. The capillary permeability surface product was found to be significantly increased in central nervous system lymphomas compared with glioblastoma multiforme, medulloblastomas, and metastases. Tumoral blood flow was significantly greater than in normal white matter. Our results suggest favorable pharmacokinetics to water‐ and lipid‐soluble drugs in primary central nervous system lymphomas. Ann Neurol 2005;57:136–139

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