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Capillary electrophoresis and small molecule drug discovery: a perfect match?

โœ Scribed by Alfonso Espada; Manuel Molina-Martin


Book ID
113569478
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
447 KB
Volume
17
Category
Article
ISSN
1359-6446

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We developed a rapid screening method for determination of pK(a) of candidate drugs by pressure-assisted capillary electrophoresis (CE) coupled with a photodiode array detector. Application of pressure during CE analysis allowed completion of one CE run in less than 1 min, and the obtained pH-metric