Capacity to solubilize immune complexes in sera and synovial fluids from patients with rheumatoid arthritis

✍ Scribed by E. Dayer; J. C. Gerster; M. T. Aguado; P. H. Lambert

• Publisher: John Wiley and Sons
• Year: 1983
• Tongue: English
• Weight: 757 KB
• Volume: 26
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/art.1780260206

✦ Synopsis

Abstract

Fifty‐six sera and 33 synovial fluids from rheumatoid arthritis patients were studied to evaluate their capacity to solubilize immune complexes. A decreased function was found in 65% of rheumatoid synovial fluids when compared with 13 osteoarthritis synovial fluids. The decrease of immune complex solubilization capacity correlated with the decrease of hemolytic activity of the alternative complement pathway (P < 0.001) and inversely with the level of immune complexes (P < 0.05). Synovial fluids with low and normal immune complex solubilization capacity were compared; the results confirmed a possible role of the synovial complement system in modulating the size and thus the diffusion and clearance of locally generated immune complexes.