Capacity of working memory in rats as determined by performance on a radial maze
β Scribed by O. Buresova; J. Bures
- Book ID
- 118409242
- Publisher
- Elsevier Science
- Year
- 1982
- Tongue
- French
- Weight
- 622 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0376-6357
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π SIMILAR VOLUMES
Nicotine and other nicotinic agonists have been found to improve performance in a variety of tasks, including the radial-arm maze to improve memory. There has been an active effort to develop novel nicotinic agonists for the treatment of cognitive dysfunction such as is seen in Alzheimer's disease.
The effect of physostigmine (0.2mg/kg), scopolamine (0.1 mg/kg), d,/-amphetamine (1 mg/kg), apomorphine (0.05 mg/kg), and piracetam (100 mg/kg) on working memory was examined in 12 rats that were highly overtrained in the radial maze. In experiment l, drugs administered 10rain before the trial did n