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Capacity of murine IL-12 to inhibit the development of primary melanoma tumors and to prevent lung metastases in the melanoma-challenged mice

✍ Scribed by David P. Shrayer; Hendrik Bogaars; Bernard Cole; Stanley F. Wolf; Harold J. Wanebo

Book ID
114424667
Publisher
Wiley (Blackwell Publishing)
Year
2002
Tongue
English
Weight
341 KB
Volume
2
Category
Article
ISSN
1533-869X

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The interleukin-I (Y (IL-I) gene was introduced by retroviral gene transfer into the A375P human melanoma cell line. Two hygromycin-resistant colonies, colony 3 and colony 6, which respectively do not and do express and release IL-I, were selected on the basis of Northern blot and ELISA. Both coloni