CAO 103 Intracardiac echocardiography: Observations in normal and diseased heart
✍ Scribed by Morgan Fu; Jui-Sung Hung
- Book ID
- 104324754
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 109 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0301-5629
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✦ Synopsis
The efficacy of EchoGen* contrast enhanced echocardiography was compared with magnetic resonance imaging (MRI) for the determination of left ventricular (LV) volumes (LVV), ejection fraction (EF) and wall motion abnormalities in an open-label study. A total of 35 evaluable patients undergoing echocardiography received a single injection of EchoGene (0.05 mL/kg iv). The LW and EF for baseline and contrast-enhanced were compared to the corresponding MRl values as a reference standard. Both linear regressions and Bland-Altman analyses showed that EchoGene enhanced echocardiography can measure end diastolic volume (EDV), end systolic volume (ESV) and EF more closely to MRI measurements than can non-contrast echocardiography. The r of the regressions improved from 0.843 to 0.879, from 0.891 to 0.941 and from 0.707 to 0.864 for EDV, ESV and EF, respectively. The Bland-Altman limits of agreement narrowed from spans of 97 mL to 85 mL, from 81 to 59 mL and from 0.37 to 0.25 for EDV, ESV and EF, respectively. In addition, EchoGen' also significantly improved diagnosis of LV impairment (correctly classified patients: EchoGen*-enhanced, 9 l%, vs unenhanced, 7 1%) and improved the ability to evaluate regional wall motion (correctly evaluated segments: EchoGe@enhanced, 77%, vs unenhanced, 65%). EchoGen@ was well tolerated; only transient paresthesia (n=l) and headache (n=l) were experienced. In conclusion, EchoGen@ improved the accuracy of assessment of LW, EF, and regional wall motion in patients undergoing echocardiography.