Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: A novel mouse model for scleroderma?

α-melanocyte–stimulating hormone suppres

α-melanocyte–stimulating hormone suppresses bleomycin-induced collagen synthesis and reduces tissue fibrosis in a mouse model of scleroderma: Melanocortin peptides as a novel treatment strategy for scleroderma?

✍ Agatha Kokot; Anca Sindrilaru; Meinhard Schiller; Cord Sunderkötter; Claus Kerkh 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 778 KB

## Abstract ## Objective Recently, we found that human dermal fibroblasts (HDFs) express melanocortin 1 receptors (MC‐1R) that bind α‐melanocyte–stimulating hormone (α‐MSH). In search of novel therapies for scleroderma (systemic sclerosis [SSc]), we used the bleomycin (BLM) model to investigate th