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Cannabinoid receptor type 1 protects against age-related bone loss by regulating osteoblast and adipocyte differentiation of bone marrow stromal cells

✍ Scribed by A.I. Idris; A. Sophocleous; E. Landao-Bassonga; M. Merkouris; G.I. Milligan; D. Baker; R.J. van't Hof; S.H. Ralston


Book ID
116321610
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
52 KB
Volume
44
Category
Article
ISSN
8756-3282

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Regulation of human bone marrow stromal
✍ IvΓ‘n CΓ‘rcamo-Orive; Ainhoa Gaztelumendi; JesΓΊs Delgado; Naiara Tejados; Akaitz D πŸ“‚ Article πŸ“… 2010 πŸ› American Society for Bone and Mineral Research 🌐 English βš– 507 KB

Although marrow adipocytes and osteoblasts derive from a common bone marrow stromal cells (BMSCs), the mechanisms that underlie osteoporosis-associated bone loss and marrow adipogenesis during prolonged steroid treatment are unclear. We show in human BMSCs (hBMSCs) that glucocorticoid receptor (GR)