Cannabinoid receptor dependent and independent anti-proliferative effects of omega-3 ethanolamides in androgen receptor positive and negative prostate cancer cell lines

Inhibition of glycogen synthase kinase-3

Inhibition of glycogen synthase kinase-3β promotes nuclear export of the androgen receptor through a CRM1-dependent mechanism in prostate cancer cell lines

✍ Stefanie V. Schütz; Marcus V. Cronauer; Ludwig Rinnab 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 247 KB 👁 1 views

## Abstract The androgen receptor (AR) is a ligand‐dependent transcription factor belonging to the steroid hormone receptor superfamily. Under normal conditions, in the absence of a ligand, the AR is localized to the cytoplasm and is actively transported into the nucleus upon binding of androgens.