Canine transmissible venereal sarcoma: Leukocyte adherence inhibition (LAI) reactivity of various lymphoid tissues of dogs with tumors at different stages of growth

✍ Scribed by Matthew W. Harding; Tsu-Ju (Thomas) Yang

• Publisher: John Wiley and Sons
• Year: 1981
• Tongue: French
• Weight: 636 KB
• Volume: 27
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910270314

✦ Synopsis

Abstract

Leukocyte adherence inhibition (LAI) reactivity of various lymphoid tissues of dogs with canine transmissible venereal sarcoma (CTVS) at different stages of growth was determined by the tube LAI test. Tumors were classified at the time of excision into progressor, steady state, and regressor stages of growth. The LAI reactivity to CTVS antigen extract of spleen, draining and non‐draining lymph‐node cells, and peripheral blood leukocytes of regressors (non‐adherence index ‐ NAI of 172.8±46.8, 148.1±64.7, 138.7±47.3, and 172.2±60.7, respectively) was significantly greater than that of progressors (46.1±20.0, 38.5±21.5, 50.2±30.0, 24,6±37.2, respectively, p <0.001) and normal dogs (47.5±22.8, 54.6±24.6, 26.7±14.0, 50.9±22.4, respectively, p<0.001). In contrast, LAI reactivity of progressor lymphoid tissues to CTVS antigen extract did not differ significantly from that of normal dogs. LAI reactivity of lymphoid tissues from steady state tumor bearers (97.9±39.2, 80.7±47.3, 87.1±40.0, 85.1±53,9, respectively) was intermediate between and significantly different from LAI reactivities of regressor (p <0.05) and progressor (p <0.01) lymphoid tissues. Significant LAI reactivity observed in regressors suggests the presence of a functional effector cell mechanism associated with spontaneous regression of CTVS. The three distinct patterns of LAI reactivity observed in tumor‐bearing dogs appear to correlate with the clinical course of tumor growth.