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Canine mitochondrial myopathy associated with reduced mitochondrial mRNA and altered cytochrome c oxidase activities in fibroblasts and skeletal muscle

✍ Scribed by Vijayasarathy, C.; Giger, Urs; Prociuk, Ulana; Patterson, Donald F.; Breitschwerdt, Edward B.; Avadhani, Narayan G.


Book ID
123065561
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
860 KB
Volume
109
Category
Article
ISSN
0300-9629

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Complete sequencing of the mitochondrial genome of 13 cell lines derived from a variety of human cancers revealed nine novel mitochondrial DNA (mtDNA) variations. One of them, m.6267G>A, is a recurrent mutation that introduces the Ala122Thr substitution in the mitochondrially encoded cytochrome c ox