Candida species isolated from nails and their in vitro susceptibility to antifungal drugs in the department of Dermatology (University of Tehran, Iran)
✍ Scribed by A.R. Khosravi; H. Shokri; P. Mansouri; F. Katiraee; T. Ziglari
- Publisher
- Masson Editeur
- Year
- 2008
- Tongue
- French
- Weight
- 252 KB
- Volume
- 18
- Category
- Article
- ISSN
- 1156-5233
No coin nor oath required. For personal study only.
✦ Synopsis
Objective. -This study presents the epidemiological aspects of patients with Candida onychomycosis and the determination of in vitro susceptibility patterns of isolated Candida species. Materials and methods. -The samples were taken from 100 patients with suspected fingernail and toenail onychomycosis. The direct microscopy and culture examinations of the nail samples were performed to identify the causal agent. To select antifungal agents, the in vitro susceptibility of the isolates was performed by disc testing.
Results. -Samples from 35 patients (35%) were positive for Candida onychomycosis. C. albicans (51.4%), C. glabrata (11.4%), C. tropicalis (8.6%), C. parapsilosis (5.7%), C. guillermondii (2.9%), C. Kefyr (2.9%) and other Candida species (17.1%) were the most frequent species isolated. Significant difference was observed between the frequency of C. albicans and other Candida species (P < 0.05). Females affected more frequently than male and in both sexes, the age group of 20-39 years old was more affected. Fingernails were affected more frequently than toenails (P < 0.05). The majority isolates were susceptible to amphotericin B (94.3%), itraconazole (91.4%), fluconazole (85.7%), and ketoconazole (85.7%), whereas only one isolate of C. albicans was susceptible to flucytosine.