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Candida antarctica lipase A in the dynamic resolution of novel furylbenzotiazol-based cyanohydrin acetates

✍ Scribed by Csaba Paizs; Monica Toşa; Cornelia Majdik; Petri Tähtinen; Florin Dan Irimie; Liisa T. Kanerva

Book ID: 104359652
Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 231 KB
Volume: 14
Category: Article
ISSN: 0957-4166
DOI: 10.1016/s0957-4166(03)00025-9

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✦ Synopsis

A series of novel (R)-furylbenzotiazol-based cyanohydrin acetates were prepared in over 90% isolated yields from the corresponding furancarbaldehydes. The one-pot method combines a basic resin to produce hydrogen cyanide from acetone cyanohydrin, an equilibrium between the formation and decomposition of furylbenzotiazol-based cyanohydrins and the unique enantioselectivity of Candida antarctica lipase A, allowing the acylation of (R)-cyanohydrins in the presence of vinyl acetate in anhydrous acetonitrile.

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