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Candicanoside A, a Novel Cytotoxic Rearranged Cholestane Glycoside from Galtonia candicans

✍ Scribed by Yoshihiro Mimaki; Minpei Kuroda; Yutaka Sashida; Takao Yamori; Takashi Tsuruo

Publisher: John Wiley and Sons
Year: 2000
Tongue: German
Weight: 82 KB
Volume: 83
Category: Article
ISSN: 0018-019X
DOI: 10.1002/1522-2675(20001004)83:10<2698::aid-hlca2698>3.0.co;2-4

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✦ Synopsis

A novel cholestane diglycoside, named candicanoside A (1), was isolated from the bulbs of Galtonia candicans by monitoring the cytotoxic activity on HL-60 leukemia cells. Candicanoside A (1) is very unique in structure, having two epoxy functionalities in its rearranged cholestane skeleton, and showed differential cytotoxicity in the Japanese Foundation for Cancer Research 38 cell-line assay.

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