SMAD7 is a prognostic marker in patients
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Jean-Louis Boulay; Gabriele Mild; Adam Lowy; Juergen Reuter; Magali Lagrange; Lu
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Article
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2003
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John Wiley and Sons
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French
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## Abstract Chromosomal region 18q21 is frequently deleted in colorectal cancer (CRC) and is associated with poor prognosis. Potential tumor suppressor mechanisms altered by 18q21 deletion include mediation of TGFฮฒ signaling by SMADs. Following the definition of __SMAD4__ deletion as a negative pre