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Cancer-specific targeting of a conditionally replicative adenovirus using mRNA translational control

✍ Scribed by Mariam A. Stoff-Khalili; Angel A. Rivera; Ana Nedeljkovic-Kurepa; Arrigo DeBenedetti; Xiao-Lin Li; Yoshinobu Odaka; Jagat Podduturi; Don A. Sibley; Gene P. Siegal; Alexander Stoff; Scott Young; Zheng B. Zhu; David T. Curiel; J. Michael Mathis

Publisher
Springer US
Year
2007
Tongue
English
Weight
585 KB
Volume
108
Category
Article
ISSN
0167-6806

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Cancer-specific targeting of an adenovir
Cancer-specific targeting of an adenovirus-delivered herpes simplex virus thymidine kinase suicide gene using translational control
✍ J. Michael Mathis; B. Jill Williams; Don A. Sibley; Jennifer L. Carroll; Jie Li; 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 533 KB

## Abstract Two technical hurdles, gene delivery and target specificity, have hindered the development of effective cancer gene therapies. In order to circumvent the problem of tumor specificity, the suicide gene, HSV‐1 thymidine kinase (HSV‐Tk), was modified with a complex 5′ upstream‐untranslated