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Cancer risk after renal transplantation in the nordic countries, 1964–1986

✍ Scribed by Sven A. Birkeland; Hans H. Storm; Lars U. Lamm; Lotti Barlow; Ingemar Blohmé; Bjorn Forsberg; Bjorn Eklund; Ole Fjeldborg; Michael Friedberg; Lars Frödin; Eystein Glattre; Stein Halvorsen; Niels V. Holm; Amt Jakobsen; Hans E. Jorgensen; Jorgen Ladefoged; Tore Lindholm; Goran Lundgren; Eero Pukkala

Publisher
John Wiley and Sons
Year
1995
Tongue
French
Weight
787 KB
Volume
60
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

The theory that cancer may arise under conditions of reduced immune capacity is supported by observations of humans with immune deficiencies such as occur following organ transplants.

However, no study on humans has been done in which the reference population was the same as that in which the cancer cases arose and in which there was a sufficiently long period of follow-up. Information on 5,692 Nordic recipients of renal transplants in 1964-1982 was linked with the national cancer registries (1964-1 986) and population registries. Person-years at risk were calculated from the date of first transplantation until death or the end of the study period and were multiplied by the appropriate age-and calender-specific incidence rates to obtain the expected numbers of cancers. Standardized incidence ratios (SIR) were calculated after stratification by a number of recorded variables. Altogether, 32,392 person-years were accrued, and 47 I cancers occurred, yielding overall SIR of 4.6 (95% CI, 4.0 to 5.2) for males and 4.5 (95% CI, 4.0 to 5.2) for females. Significant overall 2to 5-fold excess risks in both sexes were seen for cancers of the colon, larynx, lung and bladder, and in men also for cancers of the prostate and testis. Notably high risks, 10-fold to 30-fold above expectation, were associated with cancers of the lip, skin (non-melanoma), kidney and endocrine glands, also with non-Hodgkin's lymphoma, and in women also with cancers of the cervix and vulva-vagina. Among a number of donor and recipient variables studied, including tissue types and compatibility (ABO, HLA, DR). age below 45

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