✦ LIBER ✦

Cancer progression: The ultimate challenge

✍ Scribed by Renato Dulbecco

Book ID: 102276775
Publisher: John Wiley and Sons
Year: 1989
Tongue: French
Weight: 471 KB
Volume: 44
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910440704

No coin nor oath required. For personal study only.

✦ Synopsis

I present a new hypothesis for cancer progression, based on observations with experimental tumors and on our growing understanding of the regulation of gene expression in mammalian cells. The experimental observations demonstrate that progression has a stochastic course and is associated with profound perturbations of cell differentiation. The hypothesis proposes that an initial event (such as the activation of an oncogene) alters the state of the regulatory network that controls the expression of cellular genes, directing it to evolve in a direction not consonant with the developmental program of the genome. Possible consequences of this epigenetic hypothesis for cancer research are discussed.

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