Cancer of theEsophagus: The Wayne State University experience

✍ Scribed by Lawrence Leichman

• Book ID: 104652592
• Publisher: Springer US
• Year: 1989
• Tongue: English
• Weight: 895 KB
• Volume: 7
• Category: Article
• ISSN: 0167-6997
• DOI: 10.1007/bf00178195

✦ Synopsis

The rationale for the preoperative therapy for cancer of the esophagus is described. The first trial with infusion FUra mitomycin-c and radiation performed at Wayne State University (WSU) is described. The dramatic responses were duplicated when cisplatin was substituted for mitomycin. Moreover, survival was improved over the mitomycin-c trial. These neoadjuvant trials led to a third WSU clinical trial in which the neoadjuvant therapy became the definitive therapy.