Cancer Microenvironment and Therapeutic Implications: Tumor Pathophysiology Mechanisms and Therapeutic Strategies

✍ Scribed by L. Schwartz, M. Israël, Icard Philippe (auth.), Dr. Gianfranco Baronzio, Dr. Gianfranco Fiorentini, Dr. Christopher R. Cogle (eds.)

• Publisher: Springer Netherlands
• Year: 2009
• Tongue: English
• Leaves: 247
• Edition: 1
• Category: Library

✦ Synopsis

In the post-genomic era, cancer is a genetic disease. However, cancer genotype does not always equal cancer phenotype. Cancers with the same genetic abnormalities don’t always behave the same. Understanding and eradicating cancers will require an appreciation for cancer’s ecology.

This book is the first to comprehensively explore and critically appraise cancer microenvironments and host interactions with an eye towards exploiting our understanding for new treatments. The team of contributors share amongst them impressive experiences at the laboratory bench and in the clinic. These physician-scientists have dedicated themselves to the tension between the urgency for cures and the technical challenges of discovery.

The target audience includes clinical oncologists, clinical hematologists, research oncologists, research hematologists, immunologists, stem cell researchers, oncology and hematology fellows (trainees), oncology educators (graduate and undergraduate levels), and course book for graduate students and undergraduate students.

✦ Table of Contents

Front Matter....Pages I-XV
Front Matter....Pages 1-1
Inflammation and Carcinogenesis: A Change in the Metabolic Process....Pages 3-18
Tumor Microenvironment: Aspects of Stromal-Parenchymal Interaction....Pages 19-38
Significance of Tumor Microenvironment on the Genesis of: Interstitial Fluid, Angiogenesis, Haemostatic/Haemorheologic Abnormalities. Pathogenesis and Therapeutic Aspects....Pages 39-61
Cancer, Stem Cells and the Neoplastic Niche....Pages 63-78
Front Matter....Pages 79-79
Barriers to Drug Delivery in Cancer: Clinical Implications....Pages 81-104
Hypoxia, Hyperthermia, Chemotherapy: Interactions and Opportunities....Pages 105-116
Effects of Molecularly Targeting Hypoxia in Oncology....Pages 117-135
Significance of the Tumour Microenvironment in Radiotherapy....Pages 137-156
Effects of Tumor Microenvironment on Immunity and Consequent Clinical Considerations....Pages 157-179
Effects of Tumor Microenvironment on Hyperthermia, Photodynamic and Nanotherapy....Pages 181-201
Targeting Tumour Vascularization from Bench to Bedside: Suggestions for Combination with Hyperthermia....Pages 203-219
New Indications for Established Drugs Able to Modify Tumour-Host Interactions....Pages 221-240
Back Matter....Pages 241-242

✦ Subjects

Cancer Research; Oncology; Pathology