Cancer in patients with ulcerative colitis

✍ Scribed by Lene Mellemkjaer; Jsorgen H. Olsen; Morten Frisch; Christoffer Johansen; Gloria Gridley; Joseph K. McLaughlin

• Publisher: John Wiley and Sons
• Year: 1995
• Tongue: French
• Weight: 484 KB
• Volume: 60
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910600309

✦ Synopsis

A cohort of 5,546 ulcerative colitis patients was identified from the Danish Hospital Discharge Register for 1977-1989. Patients not included in the cohort comprised those with proctitis, those treated in outpatient clinics and those for whom follow-up was less than I year. The cohort was linked to the Danish Cancer Registry in order to assess the risks for colorectal and other cancers. The linkage revealed a significant increase in the number of colorectal cancers over that in the general population (RR = I .8; n = 42; 95% CI = I .3-2.4) with consistent relative risks during early and late follow-up. The relative risk was considerably higher among younger (20-39 years: RR = 22; n = 8; 95% CI = 9.744) than older patients (260 years: RR = 1.3; n = 25; 95% CI = 0.8-1.9). but the risk difference between patients and the general population was approximately constant across all ages. In addition, we observed a significant increase in the relative risk of hepatobiliary cancers (RR = 2.3; n = 9; 95% = 1.04.3) and a slight but significant increase in the relative risk of non-melanoma skin cancer (RR = I .4; n = 37; 95% CI = I .&I .9). In summary, our population-based study confirms the increased risk of colorectal cancer among patients with ulcerative colitis and provides new leads suggesting that hepatobiliary cancer and non-melanoma skin cancer should be considered as possible sites for future patient monitoring.